NOTE:

Dear visitor (if there is any) please note the following: The blog "Broken Radius" is hosted at Google Blogger's server. I can therefore not guarantee that your visit to the blog or any comment you write wont be recorded by the NSA. If you have any worries about this, you can visit instead my alternative blog Letters-to-a-Persian-Cat. This one is hosted at a European server which hopefully acknowledges visitors privacy.

21.9.17

Hardcover vs. E-Book

My sister works in a big public library in Berlin, and she gave me access to her E-book flat rate account. She herself is not using it at all, because of emotional reasons. It happend already several times that I call her to express my gratitude to her, when I enjoyed a new Gary Shteyngart novel, an old Philip Roth novel or another collection of short stories by Amoz Oz. But she interrupts me, and through the telefon I can almost feel her aversion for e-books. She is a romantic, for her reading is synonymous with feeling the weight of a hardcover book in your hands, changing pages by physically picking the paper between your fingertips, and using artisan bookmarks.
I fully understand this nostalgia, since without all this we would have perhaps never went beyond the stage of cuniform inscriptions on clay or hieroglyphs on Egyptian papyrus. And of course I will always advocate that books of high literary quality should be printed in equally high quality books. But for daily use, E-books have certain advantages, but also disadvantages. 


Advantages:
- smaller size and weight for a larger book collection
- adjustable font size, if you have problems reading small letters or forgot your glasses (important if you are not a teenager any more)
- Easily copy and past text, if you want to comment in a blog, or send passages to a friend or a critic
- Sand on the beach wont get stuck between the pages, but might leave scratches on the screen
- No danger that the wind will blow through your pages
Disadvantages:
- if the battery goes down, you are left alone
- at intense sun light, the screen contrast is extremely poor



Several times in our vacations on the Black Sea coast, I therefore switched back to an old-fashioned hard-cover book. It also has its advantages in certain situations:

 
Advantages:
- Excellent contrast even in the strongest sun light
- People around take you as a very intelligent person (in particular if you read a 1600 pages novel by Thomas Pynchon)
-  Sand wont cause permanent damage to it, but can temporarily get stucked between the pages
-  Operates with renewable energy (sun light)
Disadvantages:
- Reading in dark environment requires an extra light source
- Strong wind will turn over pages unwantedly or even tear pages
- with bad vision, one needs spectacles



12.9.17

Hidden Power

Well, other nations are involved in endless arguments about who deserves most credits for discovering the magic power of electricity. The ancient Greeks claim to have given it the name Electron, after they have noted that after rubbing amber with a piece of silk fabric the former will attracted tiny pieces of fiber (electrostatic force of differently charged bodies). Italians, however are convinced that Alessanro Volta and Galvani earn the greatest honors, since they firstly described electro-chemical potential and electro-conductivity by metals. Serbia, Croatia, Austria and Czech are still on a debate about which nationality the great magician Nicola Tesla, inventor of alternating current and of the principle of high voltage generation by electromagnetic transformers, belonged to. And of course the usual suspects England, Germany and the Netherlands earn the merits that great physicists from their countries, namely J.C. Maxwell, G. Kirchhoff and H.A.Lorentz, who formulated the electrodynamic and electromagnetic theories.
Bulgaria entered the row of great discoveries in the field only recently, when a poor tomato farmer found out that by the help of some scotch tape and iron wire from his goat fence he can make the electric power meter in his house runs slower or even stop altogether, while the entire household including his old fashioned Rakia distillery and a self designed electric red pepper roaster consumed almost unlimited kWh of energy. His patent application for this "custom designed electric perpetuum immobile" was not granted, but forwarded to the Bulgarian authorities for fraud prevention.
 But beside of such rather questionable contributions to the progress of finding cheaper and environmentally friendly forms of energy, Bulgarian artists with their great sense of style, humor and beauty started some years ago an initiative to give the electric switch boards along the streets of the capital Sofia a new, eye catching design with added value for the community. Every year I visit the city and I am amazed by their latest electric artworks.






7.9.17

Failures of the big promise: Matchmaking Algorithms

In our modern times, the biggest hope for people desperately looking for ideal partnerships are the notorious online dating and matchmaking sites. They promise to filter out Mr. or Mrs. Right from a dozen of million candidates, whom one would have otherwise never the chance to meet or to give them a trial. Even for the minimal version of real life check, the notorious One Night Stand, people on the search would had to spend decades of their life to test just a few thousands of potential partners, and already after the first few mornings-after would  probably ruined their emotional integrity completely. And this is where the online matchmakers (like Parship, GMatch, Tinder etc) discovered their market: to promise everyone desparately hunting for an ideal partner the power of computer algorithms, big data and anonymous candidate lists, which ulimately will do the job better, safer, easier and more efficient. A recent study by Samantha Joel and colleagues from three US universities, however, raises serious doubts on this promise. They show that mutial attraction between girls and boys (student volunteers) during a recorded random dating survey had next to nothing to do with a wishlist of personal characteristics that the participants had to fill in in advance. It appears that throwing dices to pick a candidate date partner is not less succesful than having powerful computer programs doing the job.

In two of their speed-dating studies, romantically unattached individuals completed more than 100 self-report measures about traits and preferences that past researchers have identified as being relevant to mate selection. Each participant met each opposite-sex participant attending a speed-dating event for a 4-min speed date. Random forests models predicted 4% to 18% of actor variance and 7% to 27% of partner variance; crucially, however, they were unable to predict relationship variance using any combination of traits and preferences reported before the dates. These results suggest that compatibility elements of human mating are challenging to predict before two people meet.

It also raises the question if we really know what is good for us, or if we simply repeat stereotypes which the public and social media always show us. Do we know, what we want ? Do we know, what we need ? Do we know, what we know ? And if have already doubts about what is really good for us, and who is really good for us, how than should a simple computer algorithm know ?

What could remaine a funny trial and error experience for young people, however, remains to often the last hope even for candidates in their second half of life. It is disappointing to see people who should be life-experienced enough putting all their hope of finding a good partner in the hand of online algorithms.

28.8.17

Crazy Project of the third kind

I had developed at least two more or less enthusiastic projects during the last 5 years or so, which had little to do with my job or my skills. But if one reads good autobiographies of gifted people, one is occasionally surprised what sudden new talents they discover and follow with great energy.

So it happened to me 6 years ago, when I had to work together with a PhD student from Iran, met her more often than nessesarry for the project, and after she left I suffered of bad heartache. So I tried to compensate this loss with developing more interest in the politics of current Iran, issues of human rights and the question why people from there leave the country to look for freedom abroad. I came across some morvellous books, like those from Amir H. Cheheltan, unfortunately still completely unknown in the West, who with describes the psychology of victims and traitors in the political system of Iran. Another one were Shahrnush Parsipur’s memories about her time in Evin prison (kissing the Sword). I developed the idea to collect letters from Iranian political prisoners, which they send to their friends or family, translate these letters into as many as possible foreign languages (in a sort of community afford) and publish them on a website. I came quite far with this project, and even had some response from foreign friends, colleagues or just internet buddies who contributed the translations. But my idea that the project could get viral did not worked out. Although I tried to promote it by inviting some famous political artists, social scientists and political activists in Germany, Europe, the US, there was not so much response. The website, however, is still active and its called Evin Rosetta.

The next funny project, with some political and some cultural and entertaining context was my plan to develop a Vineyard here in Munich, using one of the artificially made rubbish hills. It should have been a Vineyard of the Nations, because I invited people from quite different countries (Russia, US, Iran, Germany, Afghanistan, Israel) to participate. The flyer from our first meeting you can find here.

But again it appeared much harder to motivate the people to stay on board. Some simply said they had no time, others honestly expressed their doubts or their fear to do something with foreigners.

Maybe I should post an new announcement via Twitter. Although it is only for daily news, the range of readers and potential responders could be much larger.

What it takes to succesfully launch a really crazy project can be red here:

Voyagers Golden Record.

About the design of the golden data record with information about our earth, mankind and a couple of sounds and voices and music from different sources. The Golden Record was launched on board the Voyager probe to travel across the universe, and maybe being found and played by an extraterrestrial civilisation.

23.8.17

This is my favorite, but also my most painful gene : PYGM

Well, I think I can say that I am a pretty good geneticist, published at least 30 papers in internationally recognized journals that cover topics such as genetics of cancer, genetics of neurological diseases, genetics of stem cells and of embryonic development and a lot about the inherited susceptibility for diseases after environmental stress.

Now, in my early 50s, I have to anticipate that my own genome is also not free of any disease-predisposing abnormalities. I recognized some odd pain in my leg muscles about 10 years ago, when some really horribly pains struck me after walking down the stairway from our 5th floor apartment. 
After consulting various specialist doctors I ended up at the F.Miescher Clinic in Munich, which is specialize for neuro-muscular diseases. After taking a biopsy from my upper leg muscle they found that one enzyme, glycogene-phosphorylase V was completely absent. A subsequent genetic analysis that I did in our own lab confirmed that I am homozygous for a rare null-allele of the gene PYGM. McArdles disease, which is caused by this congenital condition, has a population frequency of 1 in 100.000. As in my case, both of my parents are heterozygous carriers (i.e. they carry one disease allele and one intact allele of PYGM, and due to the later they are both un-affected). I was the unlucky case of inheriting from both my mom and my dad their abnormal copy of PYGM. So I have the two bad copies in my germline, therefore I have the disease. 
O.k., I have to admit it is a disease one can live with quite easily.

There is
-  no life shortening associated
-  in my case, severe muscle pain only while climbing down (strange, I can climb up thousands of meters in the mountains, but not 10 meters downhill)
-  no problem riding the bicycle
-  no problem going dancing
-  no problem going skying (down-hill, long-distance, or touring)

When I walk down a long stairway, however, or if I climb down a hill, I got really bad muscle cramps which indicate severe destruction of muscle fibers (rhabdo-myelosis).
The only way to ease this pain in the past was to increase the glucose uptake before physical activity. But this was only partly efficient. No I got something new (and I have to admit that I found it through the internet at a patients forum:  It is a special kind of sugar (called D-Ribose, of which all our RNA molecules are made of), and it is prescribed against general muscles fatigue. The idea is, that D-Ribose can bridge the time between the depletion of glukose-generated ATP in the muscle cells and the production of new glucose from serum glycogen (which is impaired in McArdles patients) by quickly providing an energy source to the mitochondria.

I have to admit that I am not a very good biochemist, so I don't know exactly how and where D-Ribose can be used in  the mitochondrial cycle. Anyway, I believe that it works because it is based on scientific evidence.
From next week on, we will do our annual vacations in Bulgaria, and there are mountains of various levels of altitude, where I can do a controlled study with and without D-Ribose administration (because there is only a small market for D-Ribose, the stuff is about 50 x more expensive that ordinary sugar. So not really the stuff I will use to sweeten my tea with).

I will seriously report about it here. However will be the results:  These mountains are pretty impressive and beautiful anyway.  In the worst case, I will be caught on the very peak, and not being able to get home.  Than somebody has to come and catch me with a rescue helicopter.


Addenum: Maybe I should explain  why I nominated PYGM my most favorite gene: The germline mutation Arg50X (which causes expression of a truncated, inactive glycogen phosphorylase enzyme) not only predisposes strongly for McArdles disease with its sometimes painful muscles cramps, it has the beneficial side effect that the glukose level in blood serum is always quite low (because the muscle cells have to satisfy all their energy need from the free circulating glucose). This has the consequence that very little glucose is available to be converted in fatty acids and stored in the form of dad bod. So McArdle patients are usually pretty in shape, and even when they eat as much as they want, they have no problems keeping their body weight.

20.8.17

Astronomy in the Trump era

Here is what you get if a person that never in life red a book suddenly feels entitled to teach the public about what is right and what is wrong:

WASHINGTON (The Borowitz Report)—Attacking the media for its “very unfair” coverage of Monday’s solar eclipse, Donald J. Trump said on Saturday that the sun was equally to blame for blocking the moon. “The fake news is covering the eclipse from the sun’s side instead of the moon’s side, but if you look at it from the moon’s side the sun is blocking the moon’s side,” he said. “There are so many sides you can’t count all the sides.” Additionally, Trump tore into the sun itself, calling it a “showboat” for its role in the solar eclipse. “The sun thinks the world revolves around it,” Trump said. “Sad.” Trump said the sun was a “big problem” that his predecessor, Barack Obama, did nothing to solve, but that that situation was about to change. “It will be handled—we handle everything,” Trump said, adding that a preëmptive military strike on the sun was “very much on the table.”

On Monday, Trump had still doubts of the real possibility that the sun could hide behind the moon, and therefore he took a quick look to the spectacle - with bare eyes (who cares, if you are already politically blind).
Maybe he has some unused preservatives in his bath-room drawer. In this case I could instruct him how to use them for building a pair of ad-hoc eclipse protection glasses.


31.7.17

Evening confession

I sit in our garden after a day working in the lab on CrispR/Cas9 knocking out a newly discovered genome sequence from mouse zygotes. In general, I am a big proponent of new technologies, be it in IT, space research, or genetics, which is my own field of research. I do not see any reason to limit human ambitions to discover nature and to change nature, if we have good reasons that this will improve our life.
Now I sit in our garden, it is perfectly silent, only occasionally I can hear a blackbird rustling under the bushes. A dragon fly is drawing the most elegant trajectories in the air. Our dog Ivo is carefully watching me, expecting some sorts of gift. Even the big samovar, left from the garden party a few days ago, seems in perfect harmony with the flora and fauna around. The clouds are forming a pattern of self-organized stripes in the sky, and everything appears as perfectly peaceful.

I can not imagine that this is all endangered by my rational believe in the power of mankind over nature.

20.7.17

Good luck, bad luck

“You never know what worse luck your bad luck has saved you from.” 

For the staff of the Munich-Freimann fire brigade this quote by Cormac McCarthy perhaps brought small comfort, when they found their station together with the fire engines going up in flames.

 

But at least they could meet fire fighters from other places nearby, who were quickly responding to their request for help.
 

1.6.17

UNFAIR: British Tourists use unfair methods to beat the Germans on the Pool Chair Battle

New study shows that british tourists use oversized and missreplaced towels in an attempt to beat the Germans on the pool chair battle. This is an unfair method ("bad, very bad") and will soon be stoped.






British tourists are winning the sunlounger wars in Spain, waking up hours earlier than their rivals to secure a comfortable spot by the pool, an investigation into the habits of holidaymakers in Spain has revealed.
The Daily Mail reported that British tourists at a resort in Alcudia, Majorca, placing their towels on loungers to "reserve" them as early as 6am. One Briton went the extra mile by using a towel with the word "reserved" on it. By 8.51am all of the loungers were taken, but the holidaymakers were nowhere to be seen, Bild wrote.
The newspaper quoted Stephen from Barnsley, who reserved three loungers at the Bellevue Club hotel at 6am. He returned to the pool with his wife and son a full four hours later, ready to enjoy his prize.
"Luckily, I'm an early bird," he said.
The investigation follows a similar operation last year, when the newspaper visited in Lloret de Mar on the Costa Brava.



Then, not one tourist had laid down a towel by 7.36am, indicating that the towel wars have intensified in the past 12 months, forcing holidaymakers to wake up even earlier to secure a sunlounger.
Bild said that the Germans and British were the “undisputed masters” of sunbed blocking, though its investigation identified only British sunlounger hogs. Two German tourists quoted, Sabrina and Kai, both teenagers, got there too late. “When we arrived everything was already taken,” Sabrina said.
The paper called on readers to ask hotel management to remove towels because "no one has the right to a reserved lounger".
The investigation will surprise many British tourists, who complain that Germans usually beat them to the best loungers by waking early.

17.5.17

Beavis and Mike-Head

The new White House government urges CNN to work harder than ever before. The heavy load of round the clock discussion could only be dealt with by hiring news speakers from other channels.


13.5.17

Bloodhound Gang makes America great again

I was wondering what happened to the clever, naughty guys of the Bloodhound Gang. Was so silent from their side since a year or so. Now I heard an interview with Evil Jared Hasselhoff (bass, vocals) and he reveiled that the band will only go onstage again after Donald Trump leaves the White House with all his belongings.  Oh boy, I hope this happens soon.  I like their music so much.

The Ballad of Chacey Lain